Ansari M.J.I., A.D. Salama, T. Chitnis, R.N. Smith, H. Yagita, H. Akiba, M. Azuma, H. Iwai, S.J. Khoury, H. Auchincloss Jr., M.H. Sayegh. The programmed death-1 (PD-1) regulatory pathway regulates autoimmune diabetes in NOD mice. J Exp Med 2003; 198:63-9. Salama A.D., T. Chitnis, J. Imitola, H. Akiba, F. Tushima, M. Azuma, H. Yagita, M.H. Sayegh, S.J. Khoury. Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis. J Exp Med 2003; 198:71-8. Comabella, M., J. Imitola, H.L. Weiner, and S.J. Khoury. 2002. Interferon-beta treatment alters peripheral blood monocytes chemokine production in MS patients. J Neuroimmunol 126:205-212. Karni, A, DN Koldzic, P Bharanidharan, S J Khoury, and Weiner, HL. IL-18 is linked to raised IFN-gamma in multiple sclerosis and is induced by activated CD4(+) T cells via CD40-CD40 ligand interactions. J. Neuroimmunol. 2002, 125:134. Frank, M.H., M.D. Denton, S.I. Alexander, S.J. Khoury, M.H. Sayegh, and D.M. Briscoe. 2001. Specific MDR1 P-Glycoprotein Blockade Inhibits Human Alloimmune T Cell Activation In Vitro. J Immunol 166:2451-2459. Chitnis, T., N. Najafian, C. Benou, A.D. Salama, M.J. Grusby, M.H. Sayegh, and S.J. Khoury. 2001. Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J Clin Invest 108:739-747. Chitnis, T., N. Najafian, K.A. Abdallah, V. Dong, H. Yagita, M.H. Sayegh, and S.J. Khoury. 2001. CD28 independent induction of experimental autoimmune encephalomyelitis. J Clin Invest 107:575-583. Kishimoto, K., V.M. Dong, S. Issazadeh, E.V. Fedoseyeva, A.M. Waaga, A. Yamada, M. Sho, G. Benichou, H. Auchincloss, Jr., M.J. Grusby, S.J. Khoury, and M.H. Sayegh. 2000. The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo. J Clin Invest 106:63-72. Khoury, S.J., C.R. Guttmann, E.J. Orav, R. Kikinis, F.A. Jolesz, and H.L. Weiner. 2000. Changes in activated T cells in the blood correlate with disease activity in multiple sclerosis. Arch Neurol 57:1183-1189. Issazadeh, S., K. Abdallah, T. Chitnis, A. Chandraker, A.D. Wells, L.A. Turka, M.H. Sayegh, and S.J. Khoury. 2000. Role of passive T-cell death in chronic experimental autoimmune encephalomyelitis. J Clin Invest 105:1109-1116. Schaub, M., S. Issazadeh, T.H. Stadlbauer, R. Peach, M.H. Sayegh, and S.J. Khoury. 1999. Costimulatory signal blockade in murine relapsing experimental autoimmune encephalomyelitis. J Neuroimmunol 96:158-166. Khoury, S.J., E.J. Orav, C.R. Guttmann, R. Kikinis, F.A. Jolesz, and H.L. Weiner. 1999. Changes in serum levels of ICAM and TNF-R correlate with disease activity in multiple sclerosis. Neurology 53:758-764. Issazadeh S, Navikas V, Schaub M, Sayegh MH, and Khoury SJ. Kinetics of expression of costimulatory molecules and their ligands in murine relapsing experimental autoimmune encephalomyelitis in vivo. J. Immunol. 1998; 161:1104-12 Comabella, M., K. Balashov, S. Issazadeh, D. Smith, H.L. Weiner, and S.J. Khoury. 1998. Elevated interleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy [In Process Citation]. J Clin Invest 102:671-678. Chen, W., M.H. Sayegh, and S.J. Khoury. 1998. Mechanisms of acquired thymic tolerance in vivo: intrathymic injection of antigen induces apoptosis of thymocytes and peripheral T cell anergy. J Immunol 160:1504-1508. Gallon, L., A. Chandraker, S. Issazadeh, R. Peach, P.S. Linsley, L.A. Turka, M.H. Sayegh, and S.J. Khoury. 1997. Differential effects of B7-1 blockade in the rat experimental autoimmune encephalomyelitis model. J Immunol 159:4212-4216. Smith, D.R., K.E. Balashov, D.A. Hafler, S.J. Khoury, and H.L. Weiner. 1997. Immune deviation following pulse cyclophosphamide/methylprednisolone treatment of multiple sclerosis: increased interleukin-4 production and associated eosinophilia. Ann Neurol 42:313-318. Balashov, K.E., D.R. Smith, S.J. Khoury, D.A. Hafler, and H.L. Weiner. 1997. Increased interleukin 12 production in progressive multiple sclerosis: induction by activated CD4+ T cells via CD40 ligand. Proc Natl Acad Sci U S A 94:599-603. Khoury, S.J., L. Gallon, R.R. Verburg, A. Chandraker, R. Peach, P.S. Linsley, L.A. Turka, W.W. Hancock, and M.H. Sayegh. 1996. Ex vivo treatment of antigen-presenting cells with CTLA4Ig and encephalitogenic peptide prevents experimental autoimmune encephalomyelitis in the Lewis rat. J Immunol 157:3700-3705. Khoury, S.J., E. Akalin, A. Chandraker, L.A. Turka, P.S. Linsley, M.H. Sayegh, and W.W. Hancock. 1995. CD28-B7 costimulatory blockade by CTLA4Ig prevents actively induced experimental autoimmune encephalomyelitis and inhibits Th1 but spares Th2 cytokines in the central nervous system. J Immunol 155:4521-4524. Khoury, S.J., L. Gallon, W. Chen, K. Betres, M.E. Russell, W.W. Hancock, C.B. Carpenter, M.H. Sayegh, and H.L. Weiner. 1995. Mechanisms of acquired thymic tolerance in experimental autoimmune encephalomyelitis: thymic dendritic-enriched cells induce specific peripheral T cell unresponsiveness in vivo. J Exp Med 182:357-366. Balashov, K.E., S.J. Khoury, D.A. Hafler, and H.L. Weiner. 1995. Inhibition of T cell responses by activated human CD8+ T cells is mediated by interferon-gamma and is defective in chronic progressive multiple sclerosis. J Clin Invest 95:2711-2719. Khoury, S.J., C.R. Guttmann, E.J. Orav, M.J. Hohol, S.S. Ahn, L. Hsu, R. Kikinis, G.A. Mackin, F.A. Jolesz, and H.L. Weiner. 1994. Longitudinal MRI in multiple sclerosis: correlation between disability and lesion burden. Neurology 44:2120-2124. Khoury, S.J., M.H. Sayegh, W.W. Hancock, L. Gallon, C.B. Carpenter, and H.L. Weiner. 1993. Acquired tolerance to experimental autoimmune encephalomyelitis by intrathymic injection of myelin basic protein or its major encephalitogenic peptide. J Exp Med 178:559-566.