The Khoury lab is interested in multiple sclerosis and its animal model EAE. In the EAE model we are investigating methods for inducing tolerance and the basic immunopathogenic mechanisms leading to neurologic injury in this model. We have focused on costimulatory signal blockade in EAE including both positive and negative pathways. We are also investigating the interaction between the inflammatory milieu and endogenous neural stem and progenitor cells with the hope of developing therapies that promote remyelination and repair. We are also interested in developing biomarkers for disease activity in MS patients and in developing an immunologic signature for MS therapies.